A drug that is used to treat patients with advanced ovarian and breast cancer can adversely affect a woman’s fertility, scientists warn. Researchers in Australia found that olaparib, which is known by the brand name Lynparza, damaged the store of immature eggs in the ovaries of mice. Olaparib, which comes in tablet form, can destroy more than a third of the immature eggs that are contained in structures called primordial follicles, they said. Women are born with a limited number of follicles in their ovaries where eggs are stored, and damage to these follicles or eggs may lead to fertility issues. Olaparib has not been used on young women long enough to see how it affects their fertility – meaning this study could be an important indication of its effects. The drug was approved last year by the European Medicines Agency to treat women with advanced breast cancer, without knowing its effect on fertility, scientists say. Two healthy primordial follicles containing eggs are seen in this normal mouse ovary (control, left). But after olaparib (right) primordial follicle remnants lacking eggs are abundant, suggesting this new breast cancer drug kills eggs RELATED ARTICLES Previous 1 Next Keeping human embryos frozen for… Read full this story
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